Kane is dead, Nod has split into many groups, and CABAL is turning everyone into Cyborgs to create a army. In an unthinkable move, GDI & Nod team up to prevent CABAL from taking over the world through 18 single player missions. On top of all that, the world has never looked so grim before. Tiberium and it's many mutations have covered the whole planet at this point except for the few areas GDI protects. Terrible Ion Storm rage wherever Tiberium can be found, combined with the toxic nature of Tiberium to humans it is estimated hundreds of millions have died from the transformed Planet. However some Humans & Animals such as Dogs whohave been effected by Tiberium for a long time and rather then dieing they became Mutants, abominations infused with Tiberium that are not accepted by those not affected. If CABAL has his way, every Human will become a Cyborg obeying only him. Who will you fight for, man or machine?